Small Intestine
Diagram showing the small intestine
Latin	intestinum tenue
Gray's	subject #248 1168
Nerve	celiac ganglia, vagus [1]
MeSH	Small+intestine
Dorlands/Elsevier	Small intestine

In vertebrates, the small intestine is the part of the gastrointestinal tract (gut) following the stomach and followed by the large intestine, and is where the vast majority of digestion and absorption of food takes place. In invertebrates such as worms, the terms "gastrointestinal tract" and "large intestine" are often used to describe the entire intestine. This article is primarily about the human gut, though the information about its processes are directly applicable to most mammals.^[2] (A major exception to this are cows; for information about digestion in cows and other similar mammals, see ruminants.)

[edit] Size and divisions

The small intestine in an adult human measures on average about 5 meters (16 feet), with a normal range of 3 - 7 meters; it can measure around 50% longer at autopsy because of loss of smooth muscle tone after death. It is approximately 2.5-3 cm in diameter. Although the small intestine is much longer than the large intestine (typically around 3 times longer), it gets its name from its comparatively smaller diameter. Although as a simple tube the length and diameter of the small intestine would have a surface area of only about 0.5m², the surface complexity of the inner lining of the small intestine increase its surface area by a factor of 500 to approximately 200m², or roughly the size of a tennis court.

The small intestine is divided into three structural parts: ..

• Duodenum 26 cm (9.8 in) in length
• Jejunum 2.5 m (8.2 ft)
• Ileum 3.5 m (11.5 ft)

[edit] Histology

Micrograph of the small intestine mucosa showing the intestinal villi and crypts of Lieberkühn.

The three sections of the small intestine look similar to each other at a macroscopic level, but there are some important differences.

The parts of the intestine are as follows:

[edit] Digestion and absorption

Food from the stomach is allowed into the duodenum by a muscle called the pylorus, or pyloric sphincter, and is then pushed through the small intestine by a process of muscular-wavelike contractions called peristalsis.

[edit] Digestion

The small intestine is where most chemical digestion takes place. Most of the digestive enzymes that act in the small intestine are secreted by the pancreas and enter the small intestine via the pancreatic duct. The enzymes enter the small intestine in response to the hormone cholecystokinin, which is produced in the small intestine in response to the presence of nutrients. The hormone secretin also causes bicarbonate to be released into the small intestine from the pancreas in order to neutralize the potentially harmful acid coming from the stomach.

The three major classes of nutrients that undergo digestion are proteins, lipids (fats) and carbohydrates:

• Proteins and peptides are degraded into amino acids. Chemical breakdown begins in the stomach and continues in the small intestine. Proteolytic enzymes, including trypsin and chymotrypsin, are secreted by the pancreas and cleave proteins into smaller peptides. Carboxypeptidase, which is a pancreatic brush border enzyme, splits one amino acid at a time. Aminopeptidase and dipeptidase free the end amino acid products.
• Lipids (fats) are degraded into fatty acids and glycerol. Pancreatic lipase breaks down triglycerides into free fatty acids and monoglycerides. Pancreatic lipase works with the help of the salts from the bile secreted by the liver and the gall bladder. Bile salts attach to triglycerides to help emulsify them, which aids access by pancreatic lipase. This occurs because the lipase is water-soluble but the fatty triglycerides are hydrophobic and tend to orient towards each other and away from the watery intestinal surroundings. The bile salts are the "middle man" that holds the triglycerides in the watery surroundings until the lipase can break them into the smaller components that are able to enter the villi for absorption.
• Some carbohydrates are degraded into simple sugars, or monosaccharides (e.g., glucose). Pancreatic amylase breaks down some carbohydrates (notably starch) into oligosaccharides. Other carbohydrates pass undigested into the large intestine and further handling by intestinal bacteria. Brush border enzymes take over from there. The most important brush border enzymes are dextrinase and glucoamylase which further break down oligosaccharides. Other brush border enzymes are maltase, sucrase and lactase. Lactase is absent in most adult humans and for them lactose, like most poly-saccharides are not digested in the small intestine. Some carbohydrates, such as cellulose, are not digested at all, despite being made of multiple glucose units.

[edit] Absorption

Digested food is now able to pass into the blood vessels in the wall of the intestine through the process of diffusion. The small intestine is the site where most of the nutrients from ingested food are absorbed. The inner wall, or mucosa, of the small intestine is lined with simple columnar epithelial tissue. Structurally, the mucosa is covered in wrinkles or folds called plicae circulares, which are considered permanent features in the wall of the organ. They are distinct from rugae which are considered non-permanent or temporary allowing for distention and contraction. From the plicae circulares project microscopic finger-like pieces of tissue called villi (Latin for "shaggy hair"). The individual epithelial cells also have finger-like projections known as microvilli. The function of the plicae circulares, the villi and the microvilli is to increase the amount of surface area available for the absorption of nutrients.

Each villus has a network of capillaries and fine lymphatic vessels called lacteals close to its surface. The epithelial cells of the villi transport nutrients from the lumen of the intestine into these capillaries (amino acids and carbohydrates) and lacteals (lipids). The absorbed substances are transported via the blood vessels to different organs of the body where they are used to build complex substances such as the proteins required by our body. This is called diffusion. The food that remains undigested and unabsorbed passes into the large intestine.

Absorption of the majority of nutrients takes place in the jejunum, with the following notable exceptions:

• Iron is absorbed in the duodenum.
• Vitamin B12 and bile salts are absorbed in the terminal ileum.
• Water and lipids are absorbed by passive diffusion throughout the small intestine.
• Sodium is absorbed by active transport and glucose and amino acid co-transport.
• Fructose is absorbed by facilitated diffusion.

[edit] Small intestine disorders

[edit] In other animals

The small intestine is found in all tetrapods and also in teleosts, although its form and length vary enormously between species. In teleosts, it is relatively short, typically around one and a half times the length of the fish's body. It commonly has a number of pyloric caeca, small pouch-like structures along its length that help to increase the overall surface area of the organ for digesting food. There is no ileocaecal valve in teleosts, with the boundary between the small intestine and the rectum being marked only by the end of the digestive epithelium.^[3]

In tetrapods, the ileocaecal valve is always present, opening into the colon. The length of the small intestine is typically longer in tetrapods than in teleosts, but is especially so in herbivores, as well as in mammals and birds, which have a higher metabolic rate than amphibians or reptiles. The lining of the small intestine includes microscopic folds to increase its surface area in all vertebrates, but only in mammals do these develop into true villi.^[3]

The boundaries between the duodenum, jejunum, and ileum are somewhat vague even in humans, and such distinctions are either ignored when discussing the anatomy of other animals, or are essentially arbitrary.^[3]

There is no small intestine as such in non-teleost fish, such as sharks, sturgeons, and lungfish. Instead, the digestive part of the gut forms a spiral intestine, connecting the stomach to the rectum. In this type of gut, the intestine itself is relatively straight, but has a long fold running along the inner surface in a spiral fashion, sometimes for dozens of turns. This valve greatly increases both the surface area and the effective length of the intestine. The lining of the spiral intestine is similar to that of the small intestine in teleosts and non-mammalian tetrapods.^[3]

In lampreys, the spiral valve is extremely small, possibly because their diet requires little digestion. Hagfish have no spiral valve at all, with digestion occurring for almost the entire length of the intestine, which is not subdivided into different regions.^[3]

[edit] References

• Sherwood, Lauralee (2006). Fundamentals of physiology: a human perspective (Third ed.). Florence, KY: Cengage Learning. pp. 768. ISBN 0-53-446697-4. http://books.google.com/?id=GoMD0tpYgBkC. 
• Solomon et al. (2002) Biology Sixth Edition, Brooks-Cole/Thomson Learning ISBN 0-03-033503-5
• Townsend et al. (2004) Sabiston Textbook of Surgery, Elsevier ISBN 0-7216-0409-9
• Thomson A, Drozdowski L, Iordache C, Thomson B, Vermeire S, Clandinin M, Wild G (2003). "Small bowel review: Normal physiology, part 1.". Dig Dis Sci 48 (8): 1546'64. doi:10.1023/A:1024719925058. PMID 12924651. 
• Thomson A, Drozdowski L, Iordache C, Thomson B, Vermeire S, Clandinin M, Wild G (2003). "Small bowel review: Normal physiology, part 2.". Dig Dis Sci 48 (8): 1565'81. doi:10.1023/A:1024724109128. PMID 12924652. 

[edit] Notes

1. ^ Physiology at MCG 6/6ch2/s6ch2_30
2. ^ http://www.britannica.com/EBchecked/topic/275485/human-body
3. ^ ^{a b c d e} Romer, Alfred Sherwood; Parsons, Thomas S. (1977). The Vertebrate Body. Philadelphia, PA: Holt-Saunders International. pp. 349'353. ISBN 0-03-910284-X. 

[edit] Additional images

Lower half of right sympathetic cord.

Topography of thoracic and abdominal viscera.